the effect of low omega-3/omega-6 ratio on auditory nerve conduction in rat pups.
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abstract
the biological effects of omega-3 and omega-6 fatty acids are determined by their mutual interactions. this interaction extremely affects various functions. lower consumption of omega-3 during gestation leads to various disorders, even in hearing. we aimed to assess the effect of low omega-3/omega-6 ratios on auditory nerve conduction. in this experimental study, the auditory brainstem response test was performed on 24-day-old rat (n=14). the rats were divided into case (low omega-3/omega-6 ratio during gestation and lactation) and control groups. variables such as p1, p3, and p4 absolute latency period, interpeaks (p3-p4, p1-p3, and p1-p4), and p4/p1 amplitude ratio were measured. we found an increased p4 omega-3/omega-6 ratio in the group with a low omega-3/omega-6 ratio (p 0.05). also, no significant difference was observed between the groups with respect to the p1-p3 interpeak latency (ipl) periods (p>0.05); while the p1-p4 and p3-p4 ipls were significantly increased in the group with a low omega-3/omega-6 ratio (p<0.05). the p4/p1 amplitude ratio significantly decreased in the group with a low omega-3/omega-6 ratio (p<0.05). results confirmed the negative effects of low omega-3/omega-6 ratio on the auditory system and hearing.
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Journal title:
acta medica iranicaجلد ۵۳، شماره ۶، صفحات ۳۴۶-۳۵۰
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